diff --git a/documenteer/conf/pipelines.py b/documenteer/conf/pipelines.py
index 48ecb20..db6b3fc 100644
--- a/documenteer/conf/pipelines.py
+++ b/documenteer/conf/pipelines.py
@@ -14,6 +14,8 @@ This configuration is broken down into these sections:
     Intersphinx configuration
 #HTML
     HTML builder and theme configuration
+#BREATHE
+    breathe and exhale configuration for C++ reference
 #AUTOMODAPI
     automodapi and autodoc configuration
 #GRAPHVIZ
@@ -69,6 +71,9 @@ __all__ = (
     'html_show_copyright',
     'html_file_suffix',
     'html_search_language',
+    # BREATHE
+    'breathe_projects',
+    'breathe_default_project',
     # AUTOMODAPI
     'numpydoc_show_class_members',
     'autosummary_generate',
@@ -290,6 +295,13 @@ html_file_suffix = '.html'
 # Language to be used for generating the HTML full-text search index.
 html_search_language = 'en'
 
+# ============================================================================
+# #BREATHE breathe and exhale configuration for C++ reference
+# ============================================================================
+breathe_projects = {
+    "LSST": "_doxygen/xml"
+}
+breathe_default_project = "LSST"
 
 # ============================================================================
 # #AUTOMODAPI automodapi and autodoc configuration
diff --git a/documenteer/stackdocs/build.py b/documenteer/stackdocs/build.py
index 3be5aa8..dac1e96 100644
--- a/documenteer/stackdocs/build.py
+++ b/documenteer/stackdocs/build.py
@@ -12,7 +12,8 @@ from .pkgdiscovery import (
     discover_setup_packages, find_table_file, list_packages_in_eups_table,
     find_package_docs, NoPackageDocs, Package)
 from .doxygen import (
-    DoxygenConfiguration, preprocess_package_doxygen_conf, run_doxygen)
+    DoxygenConfiguration, preprocess_package_doxygen_conf, run_doxygen,
+    run_breathe_apidoc)
 from ..sphinxrunner import run_sphinx
 
 
@@ -186,8 +187,19 @@ def build_stack_docs(
 
         doxygen_conf.xml_output = doxygen_xml_dir
 
+        # Trim what's included from afw because not all of it is parseable.
+        afw_inc_path = packages['afw'].root_dir / 'include' / 'lsst' / 'afw'
+        doxygen_conf.excludes.extend([
+            afw_inc_path / 'geom' / 'SpanSet.h',
+            afw_inc_path / 'geom' / 'SpanSetFunctorGetters.h',
+        ])
+
         if enable_doxygen:
             run_doxygen(conf=doxygen_conf, root_dir=doxygen_build_dir)
+            run_breathe_apidoc(
+                xml_dir=doxygen_xml_dir,
+                project='LSST',
+                output_dir=root_project_dir / 'cpp-api')
         else:
             # Write the doxygen configuration for debugging
             doxygen_conf_path = doxygen_build_dir / 'doxygen.conf'
diff --git a/documenteer/stackdocs/doxygen.py b/documenteer/stackdocs/doxygen.py
index 22ece70..d534fbc 100644
--- a/documenteer/stackdocs/doxygen.py
+++ b/documenteer/stackdocs/doxygen.py
@@ -2,7 +2,8 @@
 """
 
 __all__ = (
-    'DoxygenConfiguration', 'preprocess_package_doxygen_conf', 'run_doxygen')
+    'DoxygenConfiguration', 'preprocess_package_doxygen_conf', 'run_doxygen',
+    'run_breathe_apidoc')
 
 from copy import deepcopy
 import csv
@@ -533,3 +534,37 @@ def run_doxygen(*, conf: DoxygenConfiguration, root_dir: Path) -> int:
         result = subprocess.run(['doxygen', str(conf_path)])
 
     return result.returncode
+
+
+def run_breathe_apidoc(
+        *, xml_dir: Path, project: str, output_dir: Path) -> int:
+    """Run breathe-apidoc to generate reStructuredText stubs for the C++
+    API reference.
+
+    Parameters
+    ----------
+    xml_dir
+        Directory containing the ``index.xml`` file generated by Doxygen.
+    project
+        Name of the Breathe project (corresponds to ``breathe_projects`` in
+        the Sphinx configuration.
+    output_dir
+        Directory where reStructuredText files are written.
+
+    Returns
+    -------
+    status
+        The shell status code returned by the ``breathe-apidoc`` executable.
+    """
+    # breathe-apidoc _doxygen/xml -o cpp-api -p LSST
+    result = subprocess.run([
+        'breathe-apidoc',
+        str(xml_dir),
+        '-o',
+        str(output_dir),
+        '-p',
+        'LSST',
+        '-f',
+        '-g',
+        'class,interface,struct,union,file,namespace,group'])
+    return result.returncode